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SKI2W
Helicase; has ATPase activity. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C). Belongs to the helicase family. SKI2 subfamily. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.6.1.-; EC 3.6.4.-; Helicase |
| Chromosomal Location of human Ortholog: 6p21.33 |
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Cellular Component:
cytosol; nucleus; Ski complex
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Molecular Function:
ATP binding; hydrolase activity; protein binding; RNA binding; RNA helicase activity
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Biological Process:
nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay; RNA catabolic process
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Disease: Trichohepatoenteric Syndrome 2
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Reference #:
Q15477
(UniProtKB)
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Alt. Names/Synonyms: 170A; DDX13; Helicase SKI2W; Helicase-like protein; HLP; SKI2; SKI2 homolog, superkiller viralicidic activity 2-like; Ski2 like RNA helicase; SKI2W; SKIV2; SKIV2L; SKIV2L1; superkiller viralicidic activity 2 (S. cerevisiae homolog)-like; superkiller viralicidic activity 2-like; superkiller viralicidic activity 2-like (S. cerevisiae); superkiller viralicidic activity 2-like homolog; THES2; W
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Gene Symbols: SKIV2L
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Molecular weight:
137,755 Da
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Basal Isoelectric point:
5.72
Predict pI for various phosphorylation states
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