SKI2W Helicase; has ATPase activity. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C). Belongs to the helicase family. SKI2 subfamily. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.1.-; EC 3.6.4.-; Helicase
Chromosomal Location of human Ortholog: 6p21.33
Cellular Component:  cytosol; nucleus; Ski complex
Molecular Function:  ATP binding; hydrolase activity; protein binding; RNA binding; RNA helicase activity
Biological Process:  nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay; RNA catabolic process
Disease: Trichohepatoenteric Syndrome 2
Reference #:  Q15477 (UniProtKB)
Alt. Names/Synonyms: 170A; DDX13; Helicase SKI2W; Helicase-like protein; HLP; SKI2; SKI2 homolog, superkiller viralicidic activity 2-like; Ski2 like RNA helicase; SKI2W; SKIV2; SKIV2L; SKIV2L1; superkiller viralicidic activity 2 (S. cerevisiae homolog)-like; superkiller viralicidic activity 2-like; superkiller viralicidic activity 2-like (S. cerevisiae); superkiller viralicidic activity 2-like homolog; THES2; W
Gene Symbols: SKIV2L
Molecular weight: 137,755 Da
Basal Isoelectric point: 5.72  Predict pI for various phosphorylation states
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SKI2W

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene