SAFB1 Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing. Can function as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription. When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter. Can inhibit cell proliferation. Ubiquitous. Expressed at high levels in the CNS and at low levels in the liver. Expressed in a wide number of breast cancer cell lines. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor co-regulator; RNA-binding
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component:  nucleoplasm
Molecular Function:  chromatin binding; double-stranded DNA binding; protein binding; RNA polymerase II proximal promoter sequence-specific DNA binding
Biological Process:  chromatin organization; hormone metabolic process; positive regulation of transcription by RNA polymerase II; regulation of growth
Reference #:  Q15424 (UniProtKB)
Alt. Names/Synonyms: DKFZp779C1727; glutathione S-transferase fusion protein; HAP; heat-shock protein (HSP27) estrogen response element and TATA box-binding protein; HET; Hsp27 ERE-TATA binding protein; HSP27 ERE-TATA-binding protein; HSP27 estrogen response element-TATA box-binding protein; SAB-B1; SAF-B; SAF-B1; SAFB; SAFB1; scaffold attachment factor B; Scaffold attachment factor B1
Gene Symbols: SAFB
Molecular weight: 102,642 Da
Basal Isoelectric point: 5.32  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  InnateDB