hnRNP E1 Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. In case of infection by poliovirus, plays a role in initiation of viral RNA replication in concert with the viral protein 3CD. Abundantly expressed in skeletal muscle, thymus and peripheral blood leukocytes while a lower expression is observed in prostate, spleen, testis, ovary, small intestine, heart, liver, adrenal and thyroid glands. Note: This description may include information from UniProtKB.
Protein type: RNA splicing; RNA-binding; Translation
Chromosomal Location of human Ortholog: 2p13.3
Cellular Component:  cytoplasm; cytoplasmic ribonucleoprotein granule; cytosol; nuclear speck; nucleoplasm; nucleus; postsynaptic density; ribonucleoprotein complex
Molecular Function:  DNA-binding transcription factor activity, RNA polymerase II-specific; mRNA binding; protein binding; RNA binding; sequence-specific single stranded DNA binding; single-stranded DNA binding
Biological Process:  positive regulation of transcription by RNA polymerase II; viral RNA genome replication
Reference #:  Q15365 (UniProtKB)
Alt. Names/Synonyms: Alpha-CP1; epididymis secretory protein Li 85; HEL-S-85; Heterogeneous nuclear ribonucleoprotein E1; heterogenous nuclear ribonucleoprotein E1; heterogenous nuclear ribonucleoprotein X; hnRNP E1; hnRNP-E1; hnRNP-X; HNRPE1; HNRPX; nucleic acid binding protein sub 2.3; Nucleic acid-binding protein SUB2.3; PCBP1; poly(rC) binding protein 1; Poly(rC)-binding protein 1
Gene Symbols: PCBP1
Molecular weight: 37,498 Da
Basal Isoelectric point: 6.66  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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hnRNP E1

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein