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hnRNP E1
Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. In case of infection by poliovirus, plays a role in initiation of viral RNA replication in concert with the viral protein 3CD. Abundantly expressed in skeletal muscle, thymus and peripheral blood leukocytes while a lower expression is observed in prostate, spleen, testis, ovary, small intestine, heart, liver, adrenal and thyroid glands. Note: This description may include information from UniProtKB.
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| Protein type: RNA splicing; RNA-binding; Translation |
| Chromosomal Location of human Ortholog: 2p13.3 |
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Cellular Component:
cytoplasm; cytoplasmic ribonucleoprotein granule; cytosol; nuclear speck; nucleoplasm; nucleus; postsynaptic density; ribonucleoprotein complex
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Molecular Function:
DNA-binding transcription factor activity, RNA polymerase II-specific; mRNA binding; protein binding; RNA binding; sequence-specific single stranded DNA binding; single-stranded DNA binding
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Biological Process:
positive regulation of transcription by RNA polymerase II; viral RNA genome replication
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Reference #:
Q15365
(UniProtKB)
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Alt. Names/Synonyms: Alpha-CP1; epididymis secretory protein Li 85; HEL-S-85; Heterogeneous nuclear ribonucleoprotein E1; heterogenous nuclear ribonucleoprotein E1; heterogenous nuclear ribonucleoprotein X; hnRNP E1; hnRNP-E1; hnRNP-X; HNRPE1; HNRPX; nucleic acid binding protein sub 2.3; Nucleic acid-binding protein SUB2.3; PCBP1; poly(rC) binding protein 1; Poly(rC)-binding protein 1
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Gene Symbols: PCBP1
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Molecular weight:
37,498 Da
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Basal Isoelectric point:
6.66
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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