PDIA6 May function as a chaperone that inhibits aggregation of misfolded proteins. Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling. May also regulate the UPR via the EIF2AK3 UPR sensor. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin. Belongs to the protein disulfide isomerase family. Expressed in platelets (at protein level). 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Isomerase
Chromosomal Location of Human Ortholog: 2p25.1
Cellular Component:  cytosol; endoplasmic reticulum; endoplasmic reticulum chaperone complex; endoplasmic reticulum lumen; endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment; extracellular space; melanosome; plasma membrane
Molecular Function:  peptide disulfide oxidoreductase activity; protein binding; protein disulfide isomerase activity
Biological Process:  cell redox homeostasis; cellular protein metabolic process; IRE1-mediated unfolded protein response; oxidation-reduction process; post-translational protein modification; protein folding
Reference #:  Q15084 (UniProtKB)
Alt. Names/Synonyms: endoplasmic reticulum protein 5; epididymis secretory sperm binding protein; ER protein 5; ERP5; P5; PDIA6; protein disulfide isomerase family A member 6; protein disulfide isomerase family A, member 6; Protein disulfide isomerase P5; protein disulfide isomerase-associated 6; protein disulfide isomerase-related protein; Protein disulfide-isomerase A6; thioredoxin domain containing 7 (protein disulfide isomerase); Thioredoxin domain-containing protein 7; TXNDC7
Gene Symbols: PDIA6
Molecular weight: 48,121 Da
Basal Isoelectric point: 4.95  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene