Mrf-2 Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-336, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation. Represses the cytomegalovirus enhancer. Belongs to the ARID5B family. Widely expressed, including in liver (at protein level). 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 10q21.2
Cellular Component:  nucleoplasm
Molecular Function:  DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein binding; RNA polymerase II regulatory region sequence-specific DNA binding; transcription coactivator activity; transcription regulatory region DNA binding
Biological Process:  adipose tissue development; adrenal gland development; cell development; cellular response to leukemia inhibitory factor; face morphogenesis; fat cell differentiation; fat pad development; female gonad development; fibroblast migration; kidney development; liver development; male gonad development; multicellular organism growth; muscle organ morphogenesis; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; nitrogen compound metabolic process; platelet-derived growth factor receptor signaling pathway; positive regulation of DNA-binding transcription factor activity; positive regulation of nucleic acid-templated transcription; post-embryonic development; roof of mouth development; skeletal system morphogenesis
Reference #:  Q14865 (UniProtKB)
Alt. Names/Synonyms: ARI5B; ARID domain-containing protein 5B; ARID5B; AT rich interactive domain 5B (MRF1-like); AT-rich interaction domain 5B; AT-rich interactive domain 5B (MRF1-like); AT-rich interactive domain-containing protein 5B; DESRT; FLJ21150; Modulator recognition factor 2; modulator recognition factor 2 (MRF2); MRF-2; MRF1-like protein; MRF2
Gene Symbols: ARID5B
Molecular weight: 132,375 Da
Basal Isoelectric point: 8.89  Predict pI for various phosphorylation states
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Mrf-2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene