POLA2 May play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery. Belongs to the DNA polymerase alpha subunit B family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA replication; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine
Chromosomal Location of human Ortholog: 11q13.1
Cellular Component:  cytosol; nucleoplasm
Molecular Function:  DNA binding; DNA-directed DNA polymerase activity
Biological Process:  DNA biosynthetic process; DNA replication; DNA replication initiation; G1/S transition of mitotic cell cycle; telomere maintenance via semi-conservative replication
Reference #:  Q14181 (UniProtKB)
Alt. Names/Synonyms: DNA polymerase alpha 2, accessory subunit; DNA polymerase alpha 70 kDa subunit; DNA polymerase alpha subunit B; DNA-directed DNA polymerase alpha 2; DPOA2; FLJ21662; FLJ37250; POLA2; polymerase (DNA directed), alpha 2 (70kD subunit); polymerase (DNA directed), alpha 2, accessory subunit; polymerase (DNA) alpha 2, accessory subunit; polymerase (DNA-directed), alpha (70kD)
Gene Symbols: POLA2
Molecular weight: 65,948 Da
Basal Isoelectric point: 5.13  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene