|
SAFB2
Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. Expressed at high levels in the CNS and at low levels in the liver. Expressed in a wide number of breast cancer cell lines. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Nuclear receptor co-regulator; RNA-binding |
| Chromosomal Location of human Ortholog: 19p13.3 |
|
Cellular Component:
cytoplasm; intracellular membrane-bounded organelle; nuclear body; nucleoplasm; nucleus
|
|
Molecular Function:
identical protein binding; protein binding; sequence-specific DNA binding
|
|
Biological Process:
regulation of androgen receptor signaling pathway; regulation of mRNA processing; regulation of transcription by RNA polymerase II; Sertoli cell differentiation
|
|
Reference #:
Q14151
(UniProtKB)
|
|
Alt. Names/Synonyms: KIAA0138; SAF-B2; SAFB2; Scaffold attachment factor B2
|
|
Gene Symbols: SAFB2
|
|
Molecular weight:
107,473 Da
|
|
Basal Isoelectric point:
5.84
Predict pI for various phosphorylation states
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
