CKAP5 Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension. Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments. Belongs to the TOG/XMAP215 family. Overexpressed in hepatomas and colonic tumors. Also expressed in skeletal muscle, brain, heart, placenta, lung, liver, kidney and pancreas. Expression is elevated in the brain; highly expressed in the Purkinje cell bodies of the cerebellum. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Motility/polarity/chemotaxis
Chromosomal Location of human Ortholog: 11p11.2
Cellular Component:  centrosome; condensed chromosome kinetochore; cytosol; kinetochore; nucleolus; plasma membrane; protein-containing complex; spindle pole
Molecular Function:  protein binding
Biological Process:  cell division; centrosome cycle; ciliary basal body-plasma membrane docking; establishment or maintenance of microtubule cytoskeleton polarity; G2/M transition of mitotic cell cycle; microtubule depolymerization; microtubule polymerization; regulation of G2/M transition of mitotic cell cycle; RNA transport; spindle organization
Reference #:  Q14008 (UniProtKB)
Alt. Names/Synonyms: Ch-TOG; CHTOG; CKAP5; Colonic and hepatic tumor over-expressed gene protein; Colonic and hepatic tumor overexpressed gene protein; cytoskeleton associated protein 5; Cytoskeleton-associated protein 5; FLJ35359; KIAA0097; MSPS; TOG; TOGp; XMAP215
Gene Symbols: CKAP5
Molecular weight: 225,495 Da
Basal Isoelectric point: 7.95  Predict pI for various phosphorylation states
CST Pathways:  Microtubule Dynamics
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein