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RRP4
Non-catalytic component of the RNA exosome complex which has 3'- Belongs to the RRP4 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.1.13.-; Nucleolus; RNA processing; Ribonuclease |
| Chromosomal Location of Human Ortholog: 9q34.12 |
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Cellular Component:
cytoplasm; cytosol; exosome (RNase complex); nuclear exosome (RNase complex); nucleolus; nucleoplasm; nucleus
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Molecular Function:
3'-5'-exoribonuclease activity; 7S RNA binding; protein binding
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Biological Process:
exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay; positive regulation of cell growth; regulation of mRNA stability; rRNA processing
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Disease: Short Stature, Hearing Loss, Retinitis Pigmentosa, And Distinctive Facies
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Reference #:
Q13868
(UniProtKB)
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Alt. Names/Synonyms: EXOS2; EXOSC2; Exosome complex component RRP4; Exosome complex exonuclease RRP4; Exosome component 2; homolog of yeast RRP4 (ribosomal RNA processing 4), 3' 5' exoribonuclease (RRP4); homolog of yeast RRP4 (ribosomal RNA processing 4), 3'-5'-exoribonuclease; hRrp4p; p7; Ribosomal RNA-processing protein 4; RRP4; Rrp4p
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Gene Symbols: EXOSC2
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Molecular weight:
32,789 Da
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Basal Isoelectric point:
7.06
Predict pI for various phosphorylation states
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