RRP4 Non-catalytic component of the RNA exosome complex which has 3'- Belongs to the RRP4 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.13.-; Nucleolus; RNA processing; Ribonuclease
Chromosomal Location of human Ortholog: 9q34.12
Cellular Component:  cytoplasm; cytosol; exosome (RNase complex); nuclear exosome (RNase complex); nucleolus; nucleoplasm; nucleus
Molecular Function:  3'-5'-exoribonuclease activity; 7S RNA binding; protein binding
Biological Process:  exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay; positive regulation of cell growth; regulation of mRNA stability; rRNA processing
Disease: Short Stature, Hearing Loss, Retinitis Pigmentosa, And Distinctive Facies
Reference #:  Q13868 (UniProtKB)
Alt. Names/Synonyms: EXOS2; EXOSC2; Exosome complex component RRP4; Exosome complex exonuclease RRP4; Exosome component 2; homolog of yeast RRP4 (ribosomal RNA processing 4), 3' 5' exoribonuclease (RRP4); homolog of yeast RRP4 (ribosomal RNA processing 4), 3'-5'-exoribonuclease; hRrp4p; p7; Ribosomal RNA-processing protein 4; RRP4; Rrp4p; SHRF
Gene Symbols: EXOSC2
Molecular weight: 32,789 Da
Basal Isoelectric point: 7.06  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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