PWP1 Chromatin-associated factor that regulates transcription. Regulates Pol I-mediated rRNA biogenesis and, probably, Pol III-mediated transcription. Regulates the epigenetic status of rDNA. Belongs to the WD repeat PWP1 family. High levels seen in the placenta, skeletal muscle, kidney and pancreas while lower levels were seen in the heart, brain and lung. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Histone-binding
Chromosomal Location of Human Ortholog: 12q23.3
Cellular Component:  chromosome; Golgi apparatus; nucleolus
Molecular Function:  H4K20me3 modified histone binding
Biological Process:  histone H4-K20 trimethylation; negative regulation of peptidyl-serine phosphorylation of STAT protein; positive regulation of stem cell differentiation; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I; ribosome biogenesis; transcription, DNA-templated
Reference #:  Q13610 (UniProtKB)
Alt. Names/Synonyms: endonuclein; IEF-SSP-9502; Keratinocyte protein IEF SSP 9502; nuclear phosphoprotein similar to S. cerevisiae PWP1; Periodic tryptophan protein 1 homolog; PWP1; PWP1 homolog (S. cerevisiae); PWP1 homolog, endonuclein
Gene Symbols: PWP1
Molecular weight: 55,828 Da
Basal Isoelectric point: 4.6  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene