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SEMA5A
Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis. Belongs to the semaphorin family. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral |
| Chromosomal Location of human Ortholog: 5p15.31 |
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Cellular Component:
membrane; plasma membrane
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Molecular Function:
chemorepellent activity; chondroitin sulfate proteoglycan binding; heparan sulfate proteoglycan binding; semaphorin receptor binding; syndecan binding
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Biological Process:
axon extension; axon guidance; axonal fasciculation; blood vessel endothelial cell proliferation involved in sprouting angiogenesis; cell adhesion; cell chemotaxis; cell-cell signaling; diencephalon development; negative chemotaxis; negative regulation of axon extension involved in axon guidance; negative regulation of cell adhesion; negative regulation of endothelial cell apoptotic process; nervous system development; neural crest cell migration; positive chemotaxis; positive regulation of actin filament depolymerization; positive regulation of angiogenesis; positive regulation of axon extension involved in axon guidance; positive regulation of canonical Wnt signaling pathway; positive regulation of cell migration; positive regulation of endothelial cell chemotaxis; positive regulation of endothelial cell proliferation; positive regulation of protein kinase B signaling; semaphorin-plexin signaling pathway; signal clustering
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Reference #:
Q13591
(UniProtKB)
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Alt. Names/Synonyms: FLJ12815; SEM5A; sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A; Sema F; SEMA5A; SEMAF; semaphorin 5A; semaphorin F; Semaphorin-5A; Semaphorin-F; semF
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Gene Symbols: SEMA5A
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Molecular weight:
120,615 Da
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Basal Isoelectric point:
7.03
Predict pI for various phosphorylation states
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