FKBP5 Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded. Widely expressed, enriched in testis compared to other tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Chaperone; EC 5.2.1.8; Isomerase
Chromosomal Location of human Ortholog: 6p21.31
Cellular Component:  cytoplasm; cytosol; nucleoplasm
Molecular Function:  FK506 binding; heat shock protein binding; peptidyl-prolyl cis-trans isomerase activity; protein binding
Biological Process:  chaperone-mediated protein folding; protein folding; protein peptidyl-prolyl isomerization; response to bacterium
Disease: Major Depressive Disorder
Reference #:  Q13451 (UniProtKB)
Alt. Names/Synonyms: 51 kDa FK506-binding protein; 51 kDa FK506-binding protein 5; 51 kDa FKBP; 54 kDa progesterone receptor-associated immunophilin; AIG6; Androgen-regulated protein 6; FF1 antigen; FK506 binding protein 5; FK506-binding protein 5; FKBP prolyl isomerase 5; FKBP-5; FKBP-51; FKBP5; FKBP51; FKBP54; HSP90-binding immunophilin; MGC111006; p54; Peptidyl-prolyl cis-trans isomerase FKBP5; peptidylprolyl cis-trans isomerase; PPIase; PPIase FKBP5; Ptg-10; Rotamase; T-cell FK506-binding protein
Gene Symbols: FKBP5
Molecular weight: 51,212 Da
Basal Isoelectric point: 5.71  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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FKBP5

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein