| FKBP5 Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded. Widely expressed, enriched in testis compared to other tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB. |
| Protein type: Chaperone; EC 5.2.1.8; Isomerase |
| Chromosomal Location of human Ortholog: 6p21.31 |
| Cellular Component: cytoplasm; cytosol; nucleoplasm |
| Molecular Function: FK506 binding; heat shock protein binding; peptidyl-prolyl cis-trans isomerase activity; protein binding |
| Biological Process: chaperone-mediated protein folding; protein folding; protein peptidyl-prolyl isomerization; response to bacterium |
| Disease: Major Depressive Disorder |
| Reference #: Q13451 (UniProtKB) |
| Alt. Names/Synonyms: 51 kDa FK506-binding protein; 51 kDa FK506-binding protein 5; 51 kDa FKBP; 54 kDa progesterone receptor-associated immunophilin; AIG6; Androgen-regulated protein 6; FF1 antigen; FK506 binding protein 5; FK506-binding protein 5; FKBP prolyl isomerase 5; FKBP-5; FKBP-51; FKBP5; FKBP51; FKBP54; HSP90-binding immunophilin; MGC111006; p54; Peptidyl-prolyl cis-trans isomerase FKBP5; peptidylprolyl cis-trans isomerase; PPIase; PPIase FKBP5; Ptg-10; Rotamase; T-cell FK506-binding protein |
| Gene Symbols: FKBP5 |
| Molecular weight: 51,212 Da |
| Basal Isoelectric point: 5.71 Predict pI for various phosphorylation states |
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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FKBP5 |
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| Cross-references to other databases:
AlphaFold
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STRING
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cBioPortal
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Wikipedia
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neXtProt
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Protein Atlas
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BioGPS
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Pfam
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