treacle Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification. Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification. 8 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Nucleolus; RNA-binding; Transcription, coactivator/corepressor
Chromosomal Location of human Ortholog: 5q32-q33.1
Cellular Component:  cytosol; fibrillar center; nucleolus; nucleus
Molecular Function:  protein binding; protein heterodimerization activity; RNA polymerase I core binding; scaffold protein binding
Biological Process:  neural crest cell development; neural crest formation; regulation of translation; skeletal system development
Disease: Treacher Collins Syndrome 1
Reference #:  Q13428 (UniProtKB)
Alt. Names/Synonyms: MFD1; nucleolar trafficking phosphoprotein; TCOF; TCOF1; TCS; TCS1; Treacher Collins syndrome protein; Treacher Collins-Franceschetti syndrome 1; Treacle; Treacle protein; treacle ribosome biogenesis factor 1
Gene Symbols: TCOF1
Molecular weight: 152,106 Da
Basal Isoelectric point: 9.06  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein