liprin alpha 1 May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Belongs to the liprin family. Liprin-alpha subfamily. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 11q13.3
Cellular Component:  cytoplasm; cytosol; focal adhesion; presynaptic active zone
Molecular Function:  protein binding
Biological Process:  cell-matrix adhesion; glutamate secretion; negative regulation of protein localization to plasma membrane; negative regulation of stress fiber assembly; neurotransmitter secretion; signal transduction
Reference #:  Q13136 (UniProtKB)
Alt. Names/Synonyms: FLJ41337; FLJ42630; FLJ43474; LAR-interacting protein 1; LIP-1; LIP.1; LIP1; LIPA1; LIPRIN; liprin alpha 1; Liprin-alpha-1; Liprin-alpha1; MGC26800; PPFIA1; Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1; protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1; PTPRF interacting protein alpha 1; PTPRF-interacting protein alpha-1
Gene Symbols: PPFIA1
Molecular weight: 135,779 Da
Basal Isoelectric point: 5.91  Predict pI for various phosphorylation states
Select Structure to View Below

liprin alpha 1

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein