MTAP Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. Ubiquitously expressed. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - cysteine and methionine; EC; Phosphorylase; Transferase
Chromosomal Location of Human Ortholog: 9p21.3
Cellular Component:  cytosol; nucleus
Molecular Function:  phosphorylase activity; protein binding
Biological Process:  interleukin-12-mediated signaling pathway; L-methionine salvage from methylthioadenosine; methylation; nucleobase-containing compound metabolic process; purine ribonucleoside salvage; response to testosterone
Disease: Diaphyseal Medullary Stenosis With Malignant Fibrous Histiocytoma
Reference #:  Q13126 (UniProtKB)
Alt. Names/Synonyms: 5'-methylthioadenosine phosphorylase; BDMF; c86fus; DMSFH; DMSMFH; epididymis luminal protein 249; epididymis secretory sperm binding protein; HEL-249; LGMBF; MeSAdo phosphorylase; methylthioadenosine phosphorylase; MSAP; MTA phosphorylase; MTAP; MTAPase; S-methyl-5'-thioadenosine phosphorylase
Gene Symbols: MTAP
Molecular weight: 31,236 Da
Basal Isoelectric point: 6.75  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene