CAF-1B Complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. Belongs to the WD repeat HIR1 family. Note: This description may include information from UniProtKB.
Protein type: DNA replication
Chromosomal Location of Human Ortholog: 21q22.12-q22.13
Cellular Component:  CAF-1 complex; cytoplasm; nuclear chromatin; nucleoplasm; nucleus; protein-containing complex
Molecular Function:  chromatin binding; histone binding; protein binding; unfolded protein binding
Biological Process:  cell cycle; chromatin assembly; DNA repair; DNA replication; DNA replication-dependent nucleosome assembly
Reference #:  Q13112 (UniProtKB)
Alt. Names/Synonyms: CAF-1; CAF-1 subunit B; CAF-1B; CAF-I 60 kDa subunit; CAF-I p60; CAF-IP60; CAF1; CAF1A; CAF1B; CAF1P60; CHAF1B; Chromatin assembly factor 1 subunit B; chromatin assembly factor 1, subunit B (p60); Chromatin assembly factor I p60 subunit; human chromatin assembly factor-I p60 subunit; M-phase phosphoprotein 7; MPHOSPH7; MPP7
Gene Symbols: CHAF1B
Molecular weight: 61,493 Da
Basal Isoelectric point: 7.18  Predict pI for various phosphorylation states
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CAF-1B

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB