FLI May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling. Involved in early embryonic development. May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation. Strongest expression in skeletal muscle with high expression also in the heart and lung. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 17p11.2
Cellular Component:  brush border; cytosol; focal adhesion; microtubule organizing center; nucleoplasm
Molecular Function:  actin binding; actin filament binding; protein binding
Biological Process:  actin cytoskeleton organization; actin filament severing; multicellular organism development
Disease: Smith-magenis Syndrome
Reference #:  Q13045 (UniProtKB)
Alt. Names/Synonyms: FLI; Fli1; flightless I actin binding protein; flightless I homolog; flightless I homolog (Drosophila); FLII; FLII actin remodeling protein; FLIL; MGC39265; Protein flightless-1 homolog
Gene Symbols: FLII
Molecular weight: 144,751 Da
Basal Isoelectric point: 5.75  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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FLI

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene