PRDM2 S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene. Belongs to the class V-like SAM-binding methyltransferase superfamily. Highly expressed in retinoblastoma cell lines and in brain tumors. Also expressed in a number of other cell lines and in brain, heart, skeletal muscle, liver and spleen. Isoform 1 is expressed in testis at much higher level than isoform 3. 4 alternative splicing and alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; DNA-binding; EC; Methyltransferase; Methyltransferase, protein lysine; Nuclear receptor co-regulator; Transcription factor
Chromosomal Location of human Ortholog: 1p36.21
Cellular Component:  Golgi apparatus; nucleus
Molecular Function:  DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; histone-lysine N-methyltransferase activity; RNA polymerase II regulatory region sequence-specific DNA binding; zinc ion binding
Biological Process:  determination of adult lifespan; histone lysine methylation; positive regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated
Reference #:  Q13029 (UniProtKB)
Alt. Names/Synonyms: GATA-3 binding protein G3B; GATA-3-binding protein G3B; HUMHOXY1; KMT8; KMT8A; Lysine N-methyltransferase 8; MTB-ZF; MTE-binding protein; PR domain 2; PR domain containing 2, with ZNF domain; PR domain zinc finger protein 2; PR domain-containing protein 2; PR/SET domain 2; PRDM2; retinoblastoma protein-binding zinc finger protein; Retinoblastoma protein-interacting zinc finger protein; RIZ; RIZ1; RIZ2; Zinc finger protein RIZ; zinc-finger DNA-binding protein
Gene Symbols: PRDM2
Molecular weight: 188,915 Da
Basal Isoelectric point: 7.02  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  Ensembl Protein