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PRDM2
S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene. Belongs to the class V-like SAM-binding methyltransferase superfamily. Highly expressed in retinoblastoma cell lines and in brain tumors. Also expressed in a number of other cell lines and in brain, heart, skeletal muscle, liver and spleen. Isoform 1 is expressed in testis at much higher level than isoform 3. 4 alternative splicing and alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: C2H2-type zinc finger protein; DNA-binding; EC 2.1.1.43; Methyltransferase; Methyltransferase, protein lysine; Nuclear receptor co-regulator; Transcription factor |
| Chromosomal Location of human Ortholog: 1p36.21 |
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Cellular Component:
Golgi apparatus; nucleoplasm; nucleus
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Molecular Function:
DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; histone H3K9 trimethyltransferase activity; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific DNA binding; zinc ion binding
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Biological Process:
chromatin remodeling; determination of adult lifespan; histone methylation; negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II
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Reference #:
Q13029
(UniProtKB)
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Alt. Names/Synonyms: GATA-3 binding protein G3B; GATA-3-binding protein G3B; HUMHOXY1; KMT8; KMT8A; Lysine N-methyltransferase 8; MTB-ZF; MTE-binding protein; PR domain 2; PR domain containing 2, with ZNF domain; PR domain zinc finger protein 2; PR domain-containing protein 2; PR/SET domain 2; PRDM2; retinoblastoma protein-binding zinc finger protein; Retinoblastoma protein-interacting zinc finger protein; RIZ; RIZ1; RIZ2; Zinc finger protein RIZ; zinc-finger DNA-binding protein
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Gene Symbols: PRDM2
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Molecular weight:
188,915 Da
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Basal Isoelectric point:
7.02
Predict pI for various phosphorylation states
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