SFRS8 Plays a role as an alternative splicing regulator. Regulate its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors. Represses the splicing of MAPT/Tau exon 10. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA splicing; RNA-binding
Chromosomal Location of Human Ortholog: 12q24.33
Cellular Component:  nucleus
Molecular Function:  protein binding; RNA binding
Biological Process:  alternative mRNA splicing, via spliceosome; negative regulation of mRNA splicing, via spliceosome
Reference #:  Q12872 (UniProtKB)
Alt. Names/Synonyms: MGC167082; SFRS8; SFSWA; SFSWAP; splicing factor SWAP; splicing factor SWAP homolog; Splicing factor, arginine/serine-rich 8; splicing factor, arginine/serine-rich 8 (suppressor-of-white-apricot homolog, Drosophila); splicing factor, arginine/serine-rich 8 (suppressor-of-white-apricot, Drosophila homolog); splicing factor, suppressor of white-apricot family; Splicing factor, suppressor of white-apricot homolog; Suppressor of white apricot protein homolog; SWAP
Gene Symbols: SFSWAP
Molecular weight: 104,822 Da
Basal Isoelectric point: 8.11  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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