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SFRS8
Plays a role as an alternative splicing regulator. Regulate its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors. Represses the splicing of MAPT/Tau exon 10. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: RNA splicing; RNA-binding |
| Chromosomal Location of human Ortholog: 12q24.33 |
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Cellular Component:
nucleus
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Molecular Function:
protein binding; RNA binding
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Biological Process:
alternative mRNA splicing, via spliceosome; mRNA 5'-splice site recognition; negative regulation of mRNA splicing, via spliceosome
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Reference #:
Q12872
(UniProtKB)
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Alt. Names/Synonyms: MGC167082; SFRS8; SFSWA; SFSWAP; splicing factor SWAP; splicing factor SWAP homolog; Splicing factor, arginine/serine-rich 8; splicing factor, arginine/serine-rich 8 (suppressor-of-white-apricot homolog, Drosophila); splicing factor, arginine/serine-rich 8 (suppressor-of-white-apricot, Drosophila homolog); splicing factor, suppressor of white-apricot family; Splicing factor, suppressor of white-apricot homolog; Suppressor of white apricot protein homolog; SWAP
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Gene Symbols: SFSWAP
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Molecular weight:
104,822 Da
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Basal Isoelectric point:
8.11
Predict pI for various phosphorylation states
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