CDH17 Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport. Expressed in the gastrointestinal tract and pancreatic duct. Not detected in kidney, lung, liver, brain, adrenal gland and skin. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 8q22.1
Cellular Component:  basolateral plasma membrane; cell junction; integral component of membrane; nucleus; plasma membrane
Molecular Function:  integrin binding; proton-dependent oligopeptide secondary active transmembrane transporter activity
Biological Process:  adherens junction organization; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell adhesion; germinal center B cell differentiation; homophilic cell adhesion via plasma membrane adhesion molecules; integrin-mediated signaling pathway; marginal zone B cell differentiation; oligopeptide transmembrane transport; oligopeptide transport; positive regulation of integrin activation by cell surface receptor linked signal transduction; spleen development
Reference #:  Q12864 (UniProtKB)
Alt. Names/Synonyms: CAD17; cadherin 17, LI cadherin (liver-intestine); cadherin-16; Cadherin-17; CDH16; CDH17; FLJ26931; HPT-1; HPT-1 cadherin; HPT1; human intestinal peptide-associated transporter HPT-1; human peptide transporter 1; Intestinal peptide-associated transporter HPT-1; LI cadherin; LI-cadherin; Liver-intestine cadherin; MGC138218; MGC142024
Gene Symbols: CDH17
Molecular weight: 92,219 Da
Basal Isoelectric point: 4.99  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CDH17

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein