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NFI-A
Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. Belongs to the CTF/NF-I family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Transcription factor |
| Chromosomal Location of human Ortholog: 1p31.3 |
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Cellular Component:
cell junction; chromatin; nucleoplasm; nucleus
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Molecular Function:
chromatin binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding
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Biological Process:
BMP signaling pathway; cartilage development; cell morphogenesis; DNA replication; exit from mitosis; gene expression; glial cell fate specification; glial cell proliferation; limb morphogenesis; neural precursor cell proliferation; neuron fate specification; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; response to wounding; retina development in camera-type eye; synapse maturation; ureter development; viral genome replication
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Disease: Brain Malformations And Urinary Tract Defects
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Reference #:
Q12857
(UniProtKB)
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Alt. Names/Synonyms: BRMUTD; CCAAT-box-binding transcription factor; CTF; DKFZp434L0422; DKFZp686J23256; FLJ39164; KIAA1439; NF-I/A; NF1-A; NFI-A; NFI-L; NFIA; Nuclear factor 1 A-type; Nuclear factor 1/A; nuclear factor I A; Nuclear factor I/A; TGGCA-binding protein
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Gene Symbols: NFIA
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Molecular weight:
55,944 Da
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Basal Isoelectric point:
8.66
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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