ASPH
Isoform 1: specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins. Isoform 8: membrane-bound Ca(2+)-sensing protein, which is a structural component of the ER-plasma membrane junctions. Isoform 8 regulates the activity of Ca(+2) released-activated Ca(+2) (CRAC) channels in T-cells. Belongs to the aspartyl/asparaginyl beta-hydroxylase family. Isoform 1 is detected in all tissues tested. Isoform 8 is mainly expressed in pancreas, heart, brain, kidney and liver. Isoform 8 is expressed in kidney (at protein level). 11 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: EC 1.14.11.16; Membrane protein, integral; Oxidoreductase |
Chromosomal Location of human Ortholog: 8q12.3 |
Cellular Component:
cortical endoplasmic reticulum; endoplasmic reticulum; endoplasmic reticulum membrane; plasma membrane; sarcoplasmic reticulum membrane
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Molecular Function:
calcium ion binding; electron transfer activity; peptidyl-aspartic acid 3-dioxygenase activity; protein binding; structural constituent of muscle; structural molecule activity
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Biological Process:
activation of cysteine-type endopeptidase activity; cell population proliferation; electron transport chain; face morphogenesis; limb morphogenesis; muscle contraction; negative regulation of cell population proliferation; pattern specification process; peptidyl-aspartic acid hydroxylation; positive regulation of proteolysis; regulation of protein depolymerization; regulation of protein stability; roof of mouth development
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Reference #:
Q12797
(UniProtKB)
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Alt. Names/Synonyms: A beta H-J-J; AAH; ASP beta-hydroxylase; Aspartate beta-hydroxylase; Aspartyl/asparaginyl beta-hydroxylase; aspartyl/asparaginyl-beta-hydroxylase; ASPH; BAH; cardiac junctin; CASQ2BP1; FDLAB; HAAH; humbug; JCTN; junctate; junctin; Peptide-aspartate beta-dioxygenase
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Gene Symbols: ASPH
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Molecular weight:
85,863 Da
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Basal Isoelectric point:
4.92
Predict pI for various phosphorylation states
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