MN1 Transcriptional activator which specifically regulates expression of TBX22 in the posterior region of the developing palate. Required during later stages of palate development for growth and medial fusion of the palatal shelves. Promotes maturation and normal function of calvarial osteoblasts, including expression of the osteoclastogenic cytokine TNFSF11/RANKL. Necessary for normal development of the membranous bones of the skull. May play a role in tumor suppression. Ubiquitously expressed. Highest levels in skeletal muscle. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor
Chromosomal Location of Human Ortholog: 22q12.1
Cellular Component: 
Biological Process:  intramembranous ossification; multicellular organism development; regulation of transcription, DNA-templated
Disease: Cebalid Syndrome; Meningioma, Familial, Susceptibility To
Reference #:  Q10571 (UniProtKB)
Alt. Names/Synonyms: bK437G10B.1 (meningioma (disrupted in balanced translocation) 1); CEBALID; dJ353E16.2; meningioma 1; meningioma (disrupted in balanced translocation) 1; meningioma (translocation balanced); meningioma chromosome region 1; MGCR; MGCR1; MGCR1-PEN; MN1; MN1 proto-oncogene, transcriptional regulator; Probable tumor suppressor protein MN1; Transcriptional activator MN1
Gene Symbols: MN1
Molecular weight: 136,001 Da
Basal Isoelectric point: 6.22  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  InnateDB