MN1 May play a role in tumor suppression. A chromosomal aberration involving MN1 may be a cause of acute myeloid leukemia (AML). Translocation t(12;22)(p13;q11) with TEL. Defects in MN1 involved in the development of meningiomas, slowly growing benign tumors derived from the arachnoidal cap cells of the leptomeninges, the soft coverings of the brain and spinal cord. Meningiomas are believed to be the most common primary tumors of the central nervous system in man. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor
Chromosomal Location of Human Ortholog: 22q12.1
Cellular Component: 
Biological Process:  intramembranous ossification; multicellular organism development; regulation of transcription, DNA-templated; transcription, DNA-dependent
Disease: Meningioma, Familial, Susceptibility To
Reference #:  Q10571 (UniProtKB)
Alt. Names/Synonyms: bK437G10B.1 (meningioma (disrupted in balanced translocation) 1); dJ353E16.2; meningioma 1; meningioma (disrupted in balanced translocation) 1; meningioma (translocation balanced); meningioma chromosome region 1; MGCR; MGCR1; MGCR1-PEN; MN1; Probable tumor suppressor protein MN1; Transcriptional activator MN1
Gene Symbols: MN1
Molecular weight: 136,001 Da
Basal Isoelectric point: 6.22  Predict pI for various phosphorylation states
Select Structure to View Below

MN1

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  InnateDB