CPSF1 Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction. Belongs to the CPSF1 family. Note: This description may include information from UniProtKB.
Protein type: RNA splicing; RNA-binding
Chromosomal Location of Human Ortholog: 8q24.3
Cellular Component:  mRNA cleavage and polyadenylation specificity factor complex; nucleoplasm
Molecular Function:  enzyme binding; mRNA 3'-UTR AU-rich region binding; protein binding
Biological Process:  mRNA 3'-end processing; mRNA export from nucleus; mRNA polyadenylation; mRNA splicing, via spliceosome; pre-mRNA cleavage required for polyadenylation; termination of RNA polymerase II transcription; tRNA splicing, via endonucleolytic cleavage and ligation
Disease: Myopia 27
Reference #:  Q10570 (UniProtKB)
Alt. Names/Synonyms: cleavage and polyadenylation specific factor 1; cleavage and polyadenylation specific factor 1, 160kDa; Cleavage and polyadenylation specificity factor 160 kDa subunit; Cleavage and polyadenylation specificity factor subunit 1; CPSF 160 kDa subunit; CPSF1; CPSF160; HSU37012; MYP27; P/cl.18; polyadenylation specificity factor
Gene Symbols: CPSF1
Molecular weight: 160,884 Da
Basal Isoelectric point: 5.99  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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