TOP2B Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Belongs to the type II topoisomerase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; DNA-binding; EC; Motility/polarity/chemotaxis; Nucleolus; Topoisomerase
Chromosomal Location of Human Ortholog: 3p24.2
Cellular Component:  cytosol; nucleoplasm; nucleus; ribonucleoprotein complex; viral integration complex
Molecular Function:  ATP binding; chromatin binding; DNA binding; DNA topoisomerase type II (ATP-hydrolyzing) activity; enzyme binding; histone deacetylase binding; metal ion binding; protein C-terminus binding; protein heterodimerization activity; protein kinase C binding
Biological Process:  axonogenesis; DNA topological change; forebrain development; neuron migration; positive regulation of single stranded viral RNA replication via double stranded DNA intermediate
Reference #:  Q02880 (UniProtKB)
Alt. Names/Synonyms: antigen MLAA-44; DNA topoisomerase 2-beta; DNA topoisomerase II beta; DNA topoisomerase II, 180 kD; DNA topoisomerase II, beta isozyme; TOP2B; top2beta; TOPIIB; topo II beta; topoisomerase (DNA) II beta 180kDa; topoisomerase II beta; topoisomerase IIb; U937 associated antigen
Gene Symbols: TOP2B
Molecular weight: 183,267 Da
Basal Isoelectric point: 8.14  Predict pI for various phosphorylation states
CST Pathways:  G2/M DNA Damage Checkpoint
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Protein Structure Not Found.

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