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AP-4
Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence 5'-CAGCTG-3'. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Transcription factor |
| Chromosomal Location of human Ortholog: 16p13.3 |
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Cellular Component:
mitochondrion; nucleus; transcriptional repressor complex
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Molecular Function:
DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; E-box binding; histone deacetylase binding; protein binding; protein homodimerization activity; sequence-specific DNA binding; transcription regulatory region DNA binding
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Biological Process:
cellular response to dexamethasone stimulus; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; negative regulation by host of viral transcription; negative regulation of cell cycle arrest; negative regulation of cell proliferation; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of DNA binding; negative regulation of transcription, DNA-templated; positive regulation by host of viral transcription; positive regulation of apoptotic process; positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; protein-containing complex assembly; regulation of mitotic cell cycle phase transition
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Reference #:
Q01664
(UniProtKB)
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Alt. Names/Synonyms: Activating enhancer-binding protein 4; AP-4; BHLHC41; Class C basic helix-loop-helix protein 41; TFAP4; Transcription factor AP-4; transcription factor AP-4 (activating enhancer binding protein 4); transcription factor AP-4 (activating enhancer-binding protein 4)
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Gene Symbols: TFAP4
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Molecular weight:
38,726 Da
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Basal Isoelectric point:
5.63
Predict pI for various phosphorylation states
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