AP-4 Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence 5'-CAGCTG-3'. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of human Ortholog: 16p13.3
Cellular Component:  mitochondrion; nucleus; transcriptional repressor complex
Molecular Function:  DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; E-box binding; histone deacetylase binding; protein binding; protein homodimerization activity; sequence-specific DNA binding; transcription regulatory region DNA binding
Biological Process:  cellular response to dexamethasone stimulus; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; negative regulation by host of viral transcription; negative regulation of cell cycle arrest; negative regulation of cell proliferation; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of DNA binding; negative regulation of transcription, DNA-templated; positive regulation by host of viral transcription; positive regulation of apoptotic process; positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; protein-containing complex assembly; regulation of mitotic cell cycle phase transition
Reference #:  Q01664 (UniProtKB)
Alt. Names/Synonyms: Activating enhancer-binding protein 4; AP-4; BHLHC41; Class C basic helix-loop-helix protein 41; TFAP4; Transcription factor AP-4; transcription factor AP-4 (activating enhancer binding protein 4); transcription factor AP-4 (activating enhancer-binding protein 4)
Gene Symbols: TFAP4
Molecular weight: 38,726 Da
Basal Isoelectric point: 5.63  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB