SFRS2 Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment. Belongs to the splicing factor SR family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA processing; RNA splicing; Spliceosome
Chromosomal Location of human Ortholog: 17q25.1
Cellular Component:  cytosol; interchromatin granule; nuclear speck; nucleoplasm; nucleus; spliceosomal complex
Molecular Function:  pre-mRNA binding; protein binding; protein kinase C binding; transcription corepressor activity
Biological Process:  mitotic cell cycle; mRNA 3'-end processing; mRNA export from nucleus; mRNA processing; mRNA splicing, via spliceosome; negative regulation of nucleic acid-templated transcription; response to vitamin E; RNA export from nucleus; RNA splicing
Reference #:  Q01130 (UniProtKB)
Alt. Names/Synonyms: PR264; Protein PR264; SC-35; SC35; serine and arginine rich splicing factor 2; Serine/arginine-rich splicing factor 2; SFRS2; SFRS2A; Splicing component, 35 kDa; Splicing factor SC35; Splicing factor, arginine/serine-rich 2; SR splicing factor 2; SRp30b; SRSF2
Gene Symbols: SRSF2
Molecular weight: 25,476 Da
Basal Isoelectric point: 11.86  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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