NUP98 Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes. Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body). Belongs to the nucleoporin GLFG family. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Nucleoporin
Chromosomal Location of human Ortholog: 11p15.4
Cellular Component:  cytosol; kinetochore; nuclear body; nuclear envelope; nuclear inclusion body; nuclear membrane; nuclear periphery; nuclear pore; nuclear pore cytoplasmic filaments; nuclear pore nuclear basket; nuclear pore outer ring; nucleoplasm; ribonucleoprotein complex
Molecular Function:  mRNA binding; nuclear localization sequence binding; promoter-specific chromatin binding; protein binding; RNA binding; serine-type peptidase activity; structural constituent of nuclear pore; transcription coactivator activity
Biological Process:  mRNA transport; nuclear pore complex assembly; nuclear pore organization; nucleocytoplasmic transport; positive regulation of DNA-templated transcription; positive regulation of mRNA splicing, via spliceosome; post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery; protein import into nucleus; proteolysis; RNA export from nucleus; telomere tethering at nuclear periphery
Reference #:  P52948 (UniProtKB)
Alt. Names/Synonyms: 96 kDa nucleoporin; 98 kDa nucleoporin; ADAR2; ADIR2; GLFG-repeat containing nucleoporin; Nuclear pore complex protein Nup96; Nuclear pore complex protein Nup98; Nuclear pore complex protein Nup98-Nup96; nucleoporin 96; nucleoporin 98 and 96 precursor; nucleoporin 98kD; nucleoporin 98kDa; Nucleoporin Nup96; Nucleoporin Nup98; NUP196; NUP96; NUP98; Nup98-96; Nup98-Nup96; NUP98/PHF23 fusion 2 protein
Gene Symbols: NUP98
Molecular weight: 197,579 Da
Basal Isoelectric point: 5.97  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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