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PAP-alpha
Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus. Belongs to the poly(A) polymerase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.7.19; RNA processing; RNA splicing; Transferase |
| Chromosomal Location of human Ortholog: 14q32.2 |
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Cellular Component:
cytoplasm; nucleoplasm; nucleus
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Molecular Function:
ATP binding; magnesium ion binding; manganese ion binding; poly(A) RNA polymerase activity; protein binding; RNA binding
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Biological Process:
cytoplasmic polyadenylation; mRNA 3'-end processing; mRNA polyadenylation; regulation of mRNA 3'-end processing
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Reference #:
P51003
(UniProtKB)
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Alt. Names/Synonyms: MGC5378; PAP; PAP-alpha; PAPOA; PAPOLA; Poly(A) polymerase alpha; Polynucleotide adenylyltransferase alpha
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Gene Symbols: PAPOLA
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Molecular weight:
82,843 Da
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Basal Isoelectric point:
6.96
Predict pI for various phosphorylation states
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