PAP-alpha Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus. Belongs to the poly(A) polymerase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.7.19; RNA processing; RNA splicing; Transferase
Chromosomal Location of human Ortholog: 14q32.2
Cellular Component:  cytoplasm; nucleoplasm; nucleus
Molecular Function:  ATP binding; magnesium ion binding; manganese ion binding; polynucleotide adenylyltransferase activity; protein binding; RNA binding
Biological Process:  mRNA 3'-end processing; mRNA polyadenylation; mRNA splicing, via spliceosome; regulation of mRNA 3'-end processing; RNA polyadenylation; termination of RNA polymerase II transcription
Reference #:  P51003 (UniProtKB)
Alt. Names/Synonyms: MGC5378; PAP; PAP-alpha; PAPOA; PAPOLA; Poly(A) polymerase alpha; Polynucleotide adenylyltransferase alpha
Gene Symbols: PAPOLA
Molecular weight: 82,843 Da
Basal Isoelectric point: 6.96  Predict pI for various phosphorylation states
Select Structure to View Below

PAP-alpha

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB