FASN Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein. Ubiquitous. Prominent expression in brain, lung, and liver. Note: This description may include information from UniProtKB.
Protein type: Acetyltransferase; EC; EC; EC; EC; EC; EC; EC; EC; Hydrolase; Lipid Metabolism - fatty acid biosynthesis; Lyase; Oxidoreductase
Chromosomal Location of Human Ortholog: 17q25.3
Cellular Component:  cytosol; glycogen granule; Golgi apparatus; melanosome; plasma membrane
Molecular Function:  (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity; 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity; 3-oxo-glutaryl-[acp] methyl ester reductase activity; 3-oxo-pimeloyl-[acp] methyl ester reductase activity; 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; 3-oxoacyl-[acyl-carrier-protein] synthase activity; [acyl-carrier-protein] S-acetyltransferase activity; [acyl-carrier-protein] S-malonyltransferase activity; drug binding; enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity; myristoyl-[acyl-carrier-protein] hydrolase activity; NADPH binding; oleoyl-[acyl-carrier-protein] hydrolase activity; palmitoyl-[acyl-carrier-protein] hydrolase activity; phosphopantetheine binding; protein binding; protein homodimerization activity
Biological Process:  acetyl-CoA metabolic process; cellular response to interleukin-4; establishment of endothelial intestinal barrier; ether lipid biosynthetic process; fatty acid biosynthetic process; fatty acid metabolic process; fatty-acyl-CoA biosynthetic process; mammary gland development; monocyte differentiation; neutrophil differentiation; oxidation-reduction process; positive regulation of cellular metabolic process; regulation of cholesterol biosynthetic process
Reference #:  P49327 (UniProtKB)
Alt. Names/Synonyms: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase; 3-oxoacyl-[acyl-carrier-protein] reductase; 3-oxoacyl-[acyl-carrier-protein] synthase; [Acyl-carrier-protein] S-acetyltransferase; [Acyl-carrier-protein] S-malonyltransferase; Acyl-[acyl-carrier-protein] hydrolase; Enoyl-[acyl-carrier-protein] reductase; FAS; FASN; Fatty acid synthase; MGC14367; MGC15706; OA-519; Oleoyl-[acyl-carrier-protein] hydrolase; SDR27X1; short chain dehydrogenase/reductase family 27X, member 1; Type I fatty acid synthase
Gene Symbols: FASN
Molecular weight: 273,427 Da
Basal Isoelectric point: 6.01  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene