NASP Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. Belongs to the NASP family. Isoform 1 is testis- and sperm-specific. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation
Chromosomal Location of human Ortholog: 1p34.1
Cellular Component:  cytoplasm; nuclear chromatin; nucleoplasm; nucleus; protein-containing complex
Molecular Function:  histone binding; protein binding
Biological Process:  blastocyst development; cell proliferation; DNA replication; DNA replication-dependent nucleosome assembly; DNA replication-independent nucleosome assembly; G1/S transition of mitotic cell cycle; histone exchange; male gonad development; protein transport; response to testosterone
Reference #:  P49321 (UniProtKB)
Alt. Names/Synonyms: DKFZp547F162; FLB7527; FLJ31599; FLJ35510; histone H1-binding protein; HMDRA1; MGC19722; MGC20372; MGC2297; N1/N2-like; NASP; NASP histone chaperone; Nuclear autoantigenic sperm protein; nuclear autoantigenic sperm protein (histone-binding); PRO1999
Gene Symbols: NASP
Molecular weight: 85,238 Da
Basal Isoelectric point: 4.26  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein