CDK4 a protein kinase of the CDK family that is important for cell cycle G1 phase progression. Its activity is restricted to the G1-S phase. Controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). Phosphorylates the retinoblastoma gene product (Rb). Point mutations found in somatic and familial melanoma. Amplified in sarcomas, glioma and lymphoma. Amplified, methylated or deleted in head and neck squamous cell carcinoma. Overexpression drives epithelial tumors in mice. Disruption makes mice resistant to cancer. Inhibitor: PD332991. Note: This description may include information from UniProtKB.
Protein type: CDK family; CDK/CDK4 subfamily; CDK4 subfamily; CMGC group; Cell cycle regulation; EC 2.7.11.22; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 12q14.1
Cellular Component:  bicellular tight junction; chromatin; cyclin D2-CDK4 complex; cyclin-dependent protein kinase holoenzyme complex; cytosol; nuclear membrane; nucleolus; nucleoplasm; nucleus; perinuclear region of cytoplasm; transcription factor complex
Molecular Function:  ATP binding; cyclin binding; cyclin-dependent protein serine/threonine kinase activity; cyclin-dependent protein serine/threonine kinase regulator activity; protein binding; protein-containing complex binding
Biological Process:  adipose tissue development; animal organ regeneration; cell division; cellular response to insulin stimulus; cellular response to interleukin-4; cellular response to ionomycin; cellular response to lipopolysaccharide; cellular response to phorbol 13-acetate 12-myristate; circadian rhythm; G1/S transition of mitotic cell cycle; lens development in camera-type eye; negative regulation of cell cycle arrest; negative regulation of G1/S transition of mitotic cell cycle; positive regulation of apoptotic process; positive regulation of cell cycle; positive regulation of cell proliferation; positive regulation of cell size; positive regulation of fibroblast proliferation; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of translation; protein phosphorylation; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of gene expression; regulation of insulin receptor signaling pathway; regulation of lipid biosynthetic process; regulation of lipid catabolic process; regulation of multicellular organism growth; response to drug; response to hyperoxia; response to lead ion; response to testosterone; response to toxic substance; signal transduction; transcription initiation from RNA polymerase II promoter
Disease: Melanoma, Cutaneous Malignant, Susceptibility To, 3
Reference #:  P11802 (UniProtKB)
Alt. Names/Synonyms: CDK4; cell division kinase 4; Cell division protein kinase 4; CMM3; Cyclin-dependent kinase 4; melanoma cutaneous malignant, 3; MGC14458; PSK-J3
Gene Symbols: CDK4
Molecular weight: 33,730 Da
Basal Isoelectric point: 6.52  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CDK4

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