utrophin May play a role in anchoring the cytoskeleton to the plasma membrane. Isoform 1 has high expression in muscle. Isoforms Up70 and Up140 were found in all the adult and fetal tissues tested and relatively abundant in lung and kidney. 3 human isoforms generated by alternative promoter usage have been reported. Note: This description may include information from UniProtKB.
Protein type: Dystrophin complex; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 6q24.2
Cellular Component:  cell junction; cortical actin cytoskeleton; cytoplasm; cytoskeleton; dystrophin-associated glycoprotein complex; filopodium; filopodium membrane; growth cone; membrane; neuromuscular junction; nucleoplasm; plasma membrane; postsynaptic membrane; protein-containing complex; sarcolemma
Molecular Function:  actin binding; actin filament binding; integrin binding; protein binding; protein kinase binding; vinculin binding; zinc ion binding
Biological Process:  muscle contraction; muscle organ development; neuromuscular junction development; positive regulation of cell-matrix adhesion; regulation of sodium ion transmembrane transporter activity; response to denervation involved in regulation of muscle adaptation
Reference #:  P46939 (UniProtKB)
Alt. Names/Synonyms: DMDL; DRP; DRP-1; DRP1; Dystrophin-related protein 1; FLJ23678; UTRN; UTRO; Utrophin
Gene Symbols: UTRN
Molecular weight: 394,466 Da
Basal Isoelectric point: 5.2  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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