matrin 3 May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. May bind to specific miRNA hairpins. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA processing; RNA-binding
Chromosomal Location of Human Ortholog: 5q31.2
Cellular Component:  nuclear inner membrane; nuclear matrix
Molecular Function:  identical protein binding; miRNA binding; protein binding; structural molecule activity; zinc ion binding
Biological Process:  activation of innate immune response; heart valve development; innate immune response; posttranscriptional regulation of gene expression; ventricular septum development
Disease: Amyotrophic Lateral Sclerosis 21
Reference #:  P43243 (UniProtKB)
Alt. Names/Synonyms: ALS21; DKFZp686K0542; DKFZp686K23100; KIAA0723; MATR3; matrin 3; Matrin-3; MGC9105; MPD2; VCPDM; vocal cord and pharyngeal weakness with distal myopathy
Gene Symbols: MATR3
Molecular weight: 94,623 Da
Basal Isoelectric point: 5.87  Predict pI for various phosphorylation states
Select Structure to View Below

matrin 3

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein