NCAPD3 Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Specifically required for decatenation of centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation
Chromosomal Location of human Ortholog: 11q25
Cellular Component:  condensed chromosome, centromeric region; condensed nuclear chromosome; condensin complex; nucleoplasm; pericentric heterochromatin
Molecular Function:  histone binding; methylated histone binding; protein binding
Biological Process:  cell division; meiotic chromosome condensation; mitotic chromosome condensation; positive regulation of chromosome condensation; positive regulation of chromosome segregation; positive regulation of chromosome separation
Disease: Microcephaly 22, Primary, Autosomal Recessive
Reference #:  P42695 (UniProtKB)
Alt. Names/Synonyms: CAP-D3; CAPD3; CNDD3; Condensin-2 complex subunit D3; FLJ42888; hCAP-D3; hcp-6; hHCP-6; KIAA0056; MCPH22; MGC104671; NCAPD3; Non-SMC condensin II complex subunit D3; non-SMC condensin II complex, subunit D3
Gene Symbols: NCAPD3
Molecular weight: 168,891 Da
Basal Isoelectric point: 7.38  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein