JARID1C Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2. Belongs to the JARID1 histone demethylase family. Expressed in all tissues examined. Highest levels found in brain and skeletal muscle. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Demethylase; EC 1.14.11.-; Oxidoreductase
Chromosomal Location of human Ortholog: Xp11.22
Cellular Component:  cytosol; nucleoplasm; nucleus
Molecular Function:  DNA binding; histone demethylase activity; histone H3K4 demethylase activity; histone H3K4me/H3K4me2/H3K4me3 demethylase activity; protein binding; zinc ion binding
Biological Process:  chromatin remodeling; histone H3-K4 demethylation; negative regulation of DNA-templated transcription; rhythmic process
Disease: Mental Retardation, X-linked, Syndromic, Claes-jensen Type
Reference #:  P41229 (UniProtKB)
Alt. Names/Synonyms: [histone H3]-trimethyl-L-lysine(4) demethylase 5C; DXS1272E; Histone demethylase JARID1C; JARID1C; JmjC domain-containing protein SMCX; Jumonji, AT rich interactive domain 1C (RBP2-like); Jumonji/ARID domain-containing protein 1C; KDM5C; lysine (K)-specific demethylase 5C; lysine demethylase 5C; Lysine-specific demethylase 5C; MRX13; MRXJ; MRXSCJ; MRXSJ; Protein SmcX; Protein Xe169; selected cDNA on X; SMCX; Smcx homolog, X chromosome; Smcy homolog, X-linked; XE169
Gene Symbols: KDM5C
Molecular weight: 175,720 Da
Basal Isoelectric point: 5.44  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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