|
JARID1C
Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2. Belongs to the JARID1 histone demethylase family. Expressed in all tissues examined. Highest levels found in brain and skeletal muscle. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Demethylase; EC 1.14.11.-; Oxidoreductase |
| Chromosomal Location of human Ortholog: Xp11.22 |
|
Cellular Component:
cytosol; nucleoplasm; nucleus
|
|
Molecular Function:
DNA binding; histone demethylase activity; histone H3K4 demethylase activity; histone H3K4me/H3K4me2/H3K4me3 demethylase activity; protein binding; zinc ion binding
|
|
Biological Process:
chromatin remodeling; histone H3-K4 demethylation; negative regulation of DNA-templated transcription; rhythmic process
|
|
Disease: Mental Retardation, X-linked, Syndromic, Claes-jensen Type
|
|
Reference #:
P41229
(UniProtKB)
|
|
Alt. Names/Synonyms: [histone H3]-trimethyl-L-lysine(4) demethylase 5C; DXS1272E; Histone demethylase JARID1C; JARID1C; JmjC domain-containing protein SMCX; Jumonji, AT rich interactive domain 1C (RBP2-like); Jumonji/ARID domain-containing protein 1C; KDM5C; lysine (K)-specific demethylase 5C; lysine demethylase 5C; Lysine-specific demethylase 5C; MRX13; MRXJ; MRXSCJ; MRXSJ; Protein SmcX; Protein Xe169; selected cDNA on X; SMCX; Smcx homolog, X chromosome; Smcy homolog, X-linked; XE169
|
|
Gene Symbols: KDM5C
|
|
Molecular weight:
175,720 Da
|
|
Basal Isoelectric point:
5.44
Predict pI for various phosphorylation states
|
|
CST Pathways:
Histone Methylation
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
