TCF8 Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family. Colocalizes with SMARCA4/BRG1 in E-cadherin-negative cells from established lines, and stroma of normal colon as well as in de-differentiated epithelial cells at the invasion front of colorectal carcinomas (at protein level). Expressed in heart and skeletal muscle, but not in liver, spleen, or pancreas. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; DNA-binding; Motility/polarity/chemotaxis; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 10p11.22
Cellular Component:  cytosol; nucleoplasm; nucleus; transcription factor complex
Molecular Function:  chromatin binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; E-box binding; protein binding; transcription coactivator activity; transcription corepressor activity; transcription factor binding; zinc ion binding
Biological Process:  cartilage development; cellular response to amino acid stimulus; central nervous system development; cochlea morphogenesis; cytokine-mediated signaling pathway; embryonic camera-type eye morphogenesis; embryonic skeletal system morphogenesis; negative regulation of cell proliferation; negative regulation of endothelial cell differentiation; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; pattern specification process; positive regulation of neuron differentiation; positive regulation of transcription by RNA polymerase II; regulation of mesenchymal cell proliferation; regulation of smooth muscle cell differentiation; regulation of T cell differentiation in thymus; regulation of transcription by RNA polymerase II; regulation of transforming growth factor beta receptor signaling pathway; semicircular canal morphogenesis
Disease: Corneal Dystrophy, Fuchs Endothelial, 6; Corneal Dystrophy, Posterior Polymorphous, 3
Reference #:  P37275 (UniProtKB)
Alt. Names/Synonyms: AREB6; BZP; delta-crystallin enhancer binding factor 1; DELTAEF1; FECD6; MGC133261; Negative regulator of IL2; NIL-2-A zinc finger protein; NIL2A; posterior polymorphous corneal dystrophy 3; PPCD3; TCF-8; TCF8; Transcription factor 8; transcription factor 8 (represses interleukin 2 expression); ZEB1; ZFHEP; ZFHX1A; zinc finger E-box binding homeobox 1; Zinc finger E-box-binding homeobox 1; zinc finger homeodomain enhancer-binding protein
Gene Symbols: ZEB1
Molecular weight: 124,074 Da
Basal Isoelectric point: 4.87  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein