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NUP214
May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex. Expressed in thymus, spleen, bone marrow, kidney, brain and testis, but hardly in all other tissues or in whole embryos during development. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Nuclear export; Nucleoporin; Oncoprotein |
| Chromosomal Location of human Ortholog: 9q34.13 |
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Cellular Component:
cytoplasmic side of nuclear pore; cytosol; nuclear envelope; nuclear pore; nucleoplasm
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Molecular Function:
nuclear export signal receptor activity; nuclear localization sequence binding; protein binding; structural constituent of nuclear pore
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Biological Process:
mRNA export from nucleus; nucleocytoplasmic transport; protein export from nucleus; protein import into nucleus; regulation of cell cycle; regulation of nucleocytoplasmic transport; RNA export from nucleus
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Disease: Encephalopathy, Acute, Infection-induced, Susceptibility To, 9; Leukemia, Acute Lymphoblastic; Leukemia, Acute Myeloid
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Reference #:
P35658
(UniProtKB)
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Alt. Names/Synonyms: 214 kDa nucleoporin; CAIN; CAN; CAN protein, putative oncogene; D9S46E; IIAE9; KIAA0023; MGC104525; N214; NU214; Nuclear pore complex protein Nup214; nucleoporin 214; nucleoporin 214kD (CAIN); nucleoporin 214kDa; Nucleoporin Nup214; NUP214; p250; Protein CAN
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Gene Symbols: NUP214
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Molecular weight:
213,620 Da
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Basal Isoelectric point:
7.15
Predict pI for various phosphorylation states
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