NUP214 May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex. Expressed in thymus, spleen, bone marrow, kidney, brain and testis, but hardly in all other tissues or in whole embryos during development. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Nuclear export; Nucleoporin; Oncoprotein
Chromosomal Location of Human Ortholog: 9q34.13
Cellular Component:  cytoplasmic side of nuclear pore; cytosol; focal adhesion; host cell; intracellular membrane-bounded organelle; nucleoplasm; nucleus
Molecular Function:  nuclear export signal receptor activity; protein binding
Biological Process:  intracellular transport of virus; mitotic cell cycle; mRNA export from nucleus; protein export from nucleus; protein sumoylation; regulation of cell cycle; regulation of cellular response to heat; regulation of gene silencing by miRNA; regulation of glycolytic process; regulation of mRNA stability; regulation of nucleocytoplasmic transport; tRNA export from nucleus; viral process; viral transcription
Disease: Encephalopathy, Acute, Infection-induced, Susceptibility To, 9; Leukemia, Acute Lymphoblastic; Leukemia, Acute Myeloid
Reference #:  P35658 (UniProtKB)
Alt. Names/Synonyms: 214 kDa nucleoporin; CAIN; CAN; CAN protein, putative oncogene; D9S46E; KIAA0023; MGC104525; N214; NU214; Nuclear pore complex protein Nup214; nucleoporin 214kD (CAIN); nucleoporin 214kDa; Nucleoporin Nup214; NUP214; p250; Protein CAN
Gene Symbols: NUP214
Molecular weight: 213,620 Da
Basal Isoelectric point: 7.15  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene