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RFC1
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Could play a role in DNA transcription regulation as well as DNA replication and/or repair. Can bind single- or double-stranded DNA. Interacts with C-terminus of PCNA. 5' phosphate residue is required for binding of the N-terminal DNA-binding domain to duplex DNA, suggesting a role in recognition of non-primer template DNA structures during replication and/or repair. Belongs to the activator 1 large subunit family. Wide tissue distribution. Undetectable in placental tissue. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA replication |
| Chromosomal Location of human Ortholog: 4p14 |
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Cellular Component:
DNA replication factor C complex; Elg1 RFC-like complex; nucleoplasm; nucleus
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Molecular Function:
ATP binding; ATP hydrolysis activity; DNA binding; DNA clamp loader activity; DNA clamp unloader activity; double-stranded DNA binding; enzyme activator activity; protein binding; protein domain specific binding; sequence-specific DNA binding
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Biological Process:
DNA clamp unloading; DNA repair; DNA-templated DNA replication; negative regulation of transcription by RNA polymerase II; positive regulation of DNA-templated transcription; telomere maintenance via telomerase
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Disease: Cerebellar Ataxia, Neuropathy, And Vestibular Areflexia Syndrome
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Reference #:
P35251
(UniProtKB)
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Alt. Names/Synonyms: A1; A1 140 kDa subunit; Activator 1 140 kDa subunit; Activator 1 large subunit; Activator 1 subunit 1; CANVAS; DNA-binding protein PO-GA; MGC51786; MHC binding factor, beta; MHCBFB; PO-GA; RECC1; replication factor C (activator 1) 1, 145kDa; Replication factor C 140 kDa subunit; Replication factor C large subunit; Replication factor C subunit 1; replication factor C1; RF-C 140 kDa subunit; RFC; RFC1; RFC140; VIPR-RP
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Gene Symbols: RFC1
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Molecular weight:
128,255 Da
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Basal Isoelectric point:
9.38
Predict pI for various phosphorylation states
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