RFC1 The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Could play a role in DNA transcription regulation as well as DNA replication and/or repair. Can bind single- or double-stranded DNA. Interacts with C-terminus of PCNA. 5' phosphate residue is required for binding of the N-terminal DNA-binding domain to duplex DNA, suggesting a role in recognition of non-primer template DNA structures during replication and/or repair. Belongs to the activator 1 large subunit family. Wide tissue distribution. Undetectable in placental tissue. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA replication
Chromosomal Location of human Ortholog: 4p14
Cellular Component:  cytoplasm; DNA replication factor C complex; Elg1 RFC-like complex; nucleolus; nucleoplasm; nucleus
Molecular Function:  ATP binding; DNA clamp loader activity; DNA clamp unloader activity; double-stranded DNA binding; enzyme activator activity; protein binding; protein domain specific binding; sequence-specific DNA binding
Biological Process:  DNA clamp unloading; DNA damage response, detection of DNA damage; DNA-dependent DNA replication; error-free translesion synthesis; error-prone translesion synthesis; negative regulation of transcription by RNA polymerase II; nucleotide-excision repair, DNA gap filling; nucleotide-excision repair, DNA incision; nucleotide-excision repair, DNA incision, 5'-to lesion; positive regulation of catalytic activity; positive regulation of transcription, DNA-templated; telomere maintenance via semi-conservative replication; telomere maintenance via telomerase; transcription-coupled nucleotide-excision repair; translesion synthesis
Disease: Cerebellar Ataxia, Neuropathy, And Vestibular Areflexia Syndrome
Reference #:  P35251 (UniProtKB)
Alt. Names/Synonyms: A1; A1 140 kDa subunit; Activator 1 140 kDa subunit; Activator 1 large subunit; Activator 1 subunit 1; CANVAS; DNA-binding protein PO-GA; MGC51786; MHC binding factor, beta; MHCBFB; PO-GA; RECC1; replication factor C (activator 1) 1, 145kDa; Replication factor C 140 kDa subunit; Replication factor C large subunit; Replication factor C subunit 1; replication factor C1; RF-C 140 kDa subunit; RFC; RFC1; RFC140; VIPR-RP
Gene Symbols: RFC1
Molecular weight: 128,255 Da
Basal Isoelectric point: 9.38  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein