CYP2C18 Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Belongs to the cytochrome P450 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cofactor and Vitamin Metabolism - retinol; EC; Lipid Metabolism - arachidonic acid; Lipid Metabolism - linoleic acid; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450
Chromosomal Location of human Ortholog: 10q23.33
Cellular Component:  cytoplasm; endoplasmic reticulum membrane; intracellular membrane-bounded organelle; plasma membrane
Molecular Function:  arachidonic acid epoxygenase activity; aromatase activity; heme binding; iron ion binding; linoleic acid epoxygenase activity; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; oxygen binding; retinoic acid 4-hydroxylase activity
Biological Process:  epoxygenase P450 pathway; linoleic acid metabolic process; retinoic acid metabolic process; retinol metabolic process; xenobiotic metabolic process
Reference #:  P33260 (UniProtKB)
Alt. Names/Synonyms: (S)-mephenytoin hydroxylase associated cytochrome P450; CP2CI; CPCI; CYP2C; CYP2C17; CYP2C18; CYPIIC18; Cytochrome P450 2C18; cytochrome P450 family 2 subfamily C member 18; cytochrome P450, family 2, subfamily C, polypeptide 18; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 17; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 18; Cytochrome P450-6b/29c; DKFZp686I24235; flavoprotein-linked monooxygenase; microsomal monooxygenase; P450-6B/29C; P450IIC17; unspecific monooxygenase
Gene Symbols: CYP2C18
Molecular weight: 55,711 Da
Basal Isoelectric point: 6.83  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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