Elf-1 Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer. Belongs to the ETS family. In fetal tissues, it is highly expressed in heart, lung liver and kidney, and weakly expressed in brain. In adult, it is highly expressed in pancreas, spleen, thymus and peripheral blood leukocytes, expressed at moderate levels in heart, placenta, lung, liver, skeletal muscle, kidney, prostate, ovary, small intestine and colon, and weakly expressed in brain and testis. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 13q14.11
Cellular Component:  nucleoplasm; nucleus
Molecular Function:  DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; RNA polymerase II proximal promoter sequence-specific DNA binding
Biological Process:  negative regulation of T cell receptor signaling pathway; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; regulation of B cell receptor signaling pathway; regulation of cytokine production; regulation of cytokine-mediated signaling pathway
Reference #:  P32519 (UniProtKB)
Alt. Names/Synonyms: E74-like factor 1; E74-like factor 1 (ets domain transcription factor); ELF1; ETS-related transcription factor Elf-1
Gene Symbols: ELF1
Molecular weight: 67,498 Da
Basal Isoelectric point: 5.09  Predict pI for various phosphorylation states
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Elf-1

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene