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Restin
Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. Detected in dendritic cells (at protein level). Highly expressed in the Reed-Sternberg cells of Hodgkin disease. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cytoskeletal |
| Chromosomal Location of human Ortholog: 12q24.31 |
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Cellular Component:
cell cortex; centrosome; cytoplasmic vesicle membrane; cytosol; intermediate filament; kinetochore; macropinosome; microtubule; microtubule cytoskeleton; microtubule plus-end; nucleus; ruffle
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Molecular Function:
microtubule binding; microtubule plus-end binding; protein binding; tubulin binding; zinc ion binding
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Biological Process:
cytoplasmic microtubule organization; microtubule bundle formation; mitotic cell cycle; positive regulation of microtubule polymerization
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Reference #:
P30622
(UniProtKB)
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Alt. Names/Synonyms: CAP-GLY domain containing linker protein 1; CAP-Gly domain-containing linker protein 1; CLIP; CLIP-170; CLIP1; CLIP170; CYLN1; cytoplasmic linker 1; Cytoplasmic linker protein 1; Cytoplasmic linker protein 170 alpha-2; cytoplasmic linker protein CLIP-170; MGC131604; Reed-Steinberg cell-expressed intermediate filament-associated protein; Reed-Sternberg intermediate filament-associated protein; Restin; restin (Reed-Steinberg cell-expressed intermediate filament-associated protein); RSN
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Gene Symbols: CLIP1
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Molecular weight:
162,246 Da
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Basal Isoelectric point:
5.29
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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