JARID1A Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif. May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1. Seems to act as a transcriptional corepressor for some genes such as MT1F and to favor the proliferation of cancer cells. Belongs to the JARID1 histone demethylase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Demethylase; EC 1.14.11.-; Nuclear receptor co-regulator; Nucleolus; Oxidoreductase; Transcription factor
Chromosomal Location of human Ortholog: 12p13.33
Cellular Component:  nucleolus; nucleoplasm; nucleus; protein-DNA complex
Molecular Function:  chromatin DNA binding; DNA binding; enzyme inhibitor activity; histone binding; histone demethylase activity; histone H3K4me/H3K4me2/H3K4me3 demethylase activity; methylated histone binding; protein binding; transcription cis-regulatory region binding; transcription coactivator activity; zinc ion binding
Biological Process:  chromatin remodeling; circadian regulation of gene expression; facultative heterochromatin formation; histone H3-K4 demethylation; negative regulation of catalytic activity; negative regulation of transcription by RNA polymerase II; positive regulation of DNA-templated transcription; regulation of DNA-binding transcription factor activity
Reference #:  P29375 (UniProtKB)
Alt. Names/Synonyms: [histone H3]-trimethyl-L-lysine(4) demethylase 5A; Histone demethylase JARID1A; JARID1A; Jumonji, AT rich interactive domain 1A (RBBP2-like); Jumonji, AT rich interactive domain 1A (RBP2-like); Jumonji/ARID domain-containing protein 1A; KDM5A; lysine (K)-specific demethylase 5A; lysine demethylase 5A; Lysine-specific demethylase 5A; RBBP-2; RBBP2; RBP2; retinoblastoma binding protein 2; Retinoblastoma-binding protein 2
Gene Symbols: KDM5A
Molecular weight: 192,095 Da
Basal Isoelectric point: 6.12  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation  |  Notch Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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