XPG Single-stranded structure-specific DNA endonuclease involved in DNA excision repair. Makes the 3'incision in DNA nucleotide excision repair (NER). Acts as a cofactor for a DNA glycosylase that removes oxidized pyrimidines from DNA. May also be involved in transcription-coupled repair of this kind of damage, in transcription by RNA polymerase II, and perhaps in other processes too. Belongs to the XPG/RAD2 endonuclease family. XPG subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage; Deoxyribonuclease; EC 3.1.-.-
Chromosomal Location of human Ortholog: 13q33.1
Cellular Component:  nucleoplasm; nucleotide-excision repair complex; nucleus
Molecular Function:  bubble DNA binding; double-stranded DNA binding; endodeoxyribonuclease activity; metal ion binding; protein binding; protein homodimerization activity; protein N-terminus binding; protein-containing complex binding; RNA polymerase II complex binding; single-stranded DNA binding
Biological Process:  negative regulation of apoptotic process; nucleotide-excision repair; nucleotide-excision repair, DNA incision; nucleotide-excision repair, DNA incision, 3'-to lesion; nucleotide-excision repair, DNA incision, 5'-to lesion; nucleotide-excision repair, preincision complex assembly; nucleotide-excision repair, preincision complex stabilization; response to UV; response to UV-C; transcription-coupled nucleotide-excision repair; UV protection
Disease: Cerebrooculofacioskeletal Syndrome 3; Xeroderma Pigmentosum, Complementation Group G
Reference #:  P28715 (UniProtKB)
Alt. Names/Synonyms: COFS3; DNA excision repair protein ERCC-5; DNA repair protein complementing XP-G cells; ERCC excision repair 5, endonuclease; ERCC5; ERCC5-201; ERCM2; excision repair cross-complementation group 5; excision repair cross-complementing rodent repair deficiency, complementation group 5; excision repair protein; UVDR; xeroderma pigmentosum complementation group G protein; Xeroderma pigmentosum group G-complementing protein; xeroderma pigmentosum, complementation group G; XPG; XPG-complementing protein; XPGC
Gene Symbols: ERCC5
Molecular weight: 133,108 Da
Basal Isoelectric point: 5.13  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene