CDK1 a protein kinase of the CDK family. Catalytic subunit of the conserved protein complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions. Mitotic cyclins stably associate with this protein and function as regulatory subunits. Its activity is controlled by cyclin availability and phosphorylation through the cell cycle. Activated in many cancers including colon, liver and breast. The T isoform, which lacks a regulatory region, is expressed in breast cancer. Inhibition in cancer cells may drive cells into apoptosis. May also drive cell migration. Inhibitors: BMS-265246, BMS-265246-01. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: CDK family; CDK/CDK1 subfamily; CDK1 subfamily; CMGC group; Cell cycle regulation; EC; EC; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 10q21.2
Cellular Component:  centrosome; cyclin B1-CDK1 complex; cyclin-dependent protein kinase holoenzyme complex; cytosol; endoplasmic reticulum membrane; midbody; mitochondrion; mitotic spindle; nucleoplasm; nucleus; spindle microtubule
Molecular Function:  ATP binding; chromatin binding; cyclin binding; cyclin-dependent protein kinase activity; cyclin-dependent protein serine/threonine kinase activity; histone kinase activity; Hsp70 protein binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; RNA polymerase II CTD heptapeptide repeat kinase activity; virus receptor activity
Biological Process:  activation of MAPK activity; anaphase-promoting complex-dependent catabolic process; animal organ regeneration; apoptotic process; cell aging; cell division; cell migration; cell proliferation; cellular response to hydrogen peroxide; centrosome cycle; chromosome condensation; ciliary basal body-plasma membrane docking; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA repair; DNA replication; epithelial cell differentiation; G2/M transition of mitotic cell cycle; Golgi disassembly; histone phosphorylation; microtubule cytoskeleton organization; mitotic G2 DNA damage checkpoint; mitotic nuclear envelope disassembly; negative regulation of apoptotic process; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of cardiac muscle cell proliferation; positive regulation of DNA replication; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of gene expression; positive regulation of mitochondrial ATP synthesis coupled electron transport; positive regulation of protein localization to nucleus; pronuclear fusion; protein deubiquitination; protein localization to kinetochore; protein phosphorylation; protein-containing complex assembly; regulation of circadian rhythm; regulation of embryonic development; regulation of G2/M transition of mitotic cell cycle; regulation of mitotic cell cycle phase transition; regulation of Schwann cell differentiation; response to activity; response to amine; response to axon injury; response to cadmium ion; response to copper ion; response to ethanol; response to organic cyclic compound; rhythmic process; transcription initiation from RNA polymerase II promoter; ventricular cardiac muscle cell development; viral entry into host cell
Reference #:  P06493 (UniProtKB)
Alt. Names/Synonyms: CDC2; CDC28A; CDK1; cell cycle controller CDC2; Cell division control protein 2 homolog; cell division cycle 2; cell division cycle 2, G1 to S and G2 to M; Cyclin-dependent kinase 1; DKFZp686L20222; MGC111195; p34 protein kinase; P34CDC2
Gene Symbols: CDK1
Molecular weight: 34,095 Da
Basal Isoelectric point: 8.38  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  ErbB/HER Signaling  |  G2/M DNA Damage Checkpoint  |  Microtubule Dynamics
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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