PSMA5 Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Belongs to the peptidase T1A family. Expressed in fetal brain (at protein level). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Protease; Proteasome complex
Chromosomal Location of human Ortholog: 1p13.3
Cellular Component:  cytoplasm; cytosol; extracellular region; ficolin-1-rich granule lumen; nucleoplasm; nucleus; proteasome complex; proteasome core complex; proteasome core complex, alpha-subunit complex; secretory granule lumen
Molecular Function:  protein binding
Biological Process:  proteasomal protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process
Reference #:  P28066 (UniProtKB)
Alt. Names/Synonyms: epididymis tissue sperm binding protein Li 11n; macropain subunit zeta; Macropain zeta chain; MGC117302; MGC125802; MGC125803; MGC125804; Multicatalytic endopeptidase complex zeta chain; proteasome (prosome, macropain) subunit, alpha type, 5; proteasome 20S subunit alpha 5; proteasome alpha 5 subunit; proteasome component 5; proteasome subunit alpha 5; Proteasome subunit alpha type-5; proteasome subunit zeta; Proteasome zeta chain; PSA5; PSC5; PSMA5; ZETA
Gene Symbols: PSMA5
Molecular weight: 26,411 Da
Basal Isoelectric point: 4.74  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene