YY1 Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence. Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions. May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In vitro, binds to DNA recombination intermediate structures (Holliday junctions). Plays a role in regulating enhancer activation. Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; proposed to target the INO80 complex to YY1-responsive elements. Belongs to the YY transcription factor family. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; Cell development/differentiation; Transcription factor
Chromosomal Location of Human Ortholog: 14q32.2
Cellular Component:  cytoplasm; Ino80 complex; nuclear matrix; nucleoplasm; nucleus
Molecular Function:  DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; enhancer sequence-specific DNA binding; four-way junction DNA binding; protein binding; proximal promoter sequence-specific DNA binding; RNA binding; SMAD binding; transcription coactivator activity; transcription corepressor activity; transcription regulatory region DNA binding; zinc ion binding
Biological Process:  anterior/posterior pattern specification; camera-type eye morphogenesis; cell differentiation; cellular response to DNA damage stimulus; cellular response to interleukin-1; cellular response to UV; chromosome organization; double-strand break repair via homologous recombination; negative regulation of cell growth involved in cardiac muscle cell development; negative regulation of gene expression; negative regulation of interferon-beta production; negative regulation of pri-miRNA transcription by RNA polymerase II; negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; protein deubiquitination; regulation of transcription by RNA polymerase II; response to prostaglandin F; response to UV-C; RNA localization; spermatogenesis
Disease: Gabriele-de Vries Syndrome
Reference #:  P25490 (UniProtKB)
Alt. Names/Synonyms: DELTA; Delta transcription factor; INO80 complex subunit S; INO80S; NF-E1; Transcriptional repressor protein YY1; TYY1; UCRBP; Yin and yang 1; Yin and Yang 1 protein; yin yang 1; YIN-YANG-1; YY-1; YY1; YY1 transcription factor
Gene Symbols: YY1
Molecular weight: 44,713 Da
Basal Isoelectric point: 5.8  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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YY1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB