RFX1 Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes. Also binds to an inverted repeat (ENH1) required for hepatitis B virus genes expression and to the most upstream element (alpha) of the RPL30 promoter. Belongs to the RFX family. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 19p13.12
Cellular Component:  intracellular membrane-bounded organelle; nucleoplasm
Molecular Function:  DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding
Biological Process:  immune response
Reference #:  P22670 (UniProtKB)
Alt. Names/Synonyms: EF-C; EFC; Enhancer factor C; MHC class II regulatory factor RFX; MHC class II regulatory factor RFX1; Regulatory factor X 1; regulatory factor X, 1 (influences HLA class II expression); regulatory factor X1; RFX; RFX1; trans-acting regulatory factor 1; Transcription factor RFX1
Gene Symbols: RFX1
Molecular weight: 104,758 Da
Basal Isoelectric point: 5.89  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene