hnRNP A2/B1 Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs. Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm. Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion. Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts. Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs. Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs. (Microbial infection) Involved in the transport of HIV-1 genomic RNA out of the nucleus, to the microtubule organizing center (MTOC), and then from the MTOC to the cytoplasm: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) sequence motifs present on HIV-1 genomic RNA, and promotes its transport. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA splicing; RNA-binding; Spliceosome
Chromosomal Location of Human Ortholog: 7p15.2
Cellular Component:  Cajal body; catalytic step 2 spliceosome; chromosome, telomeric region; cytoplasm; extracellular exosome; nuclear matrix; nucleoplasm; nucleus; ribonucleoprotein complex; spliceosomal complex
Molecular Function:  G-rich strand telomeric DNA binding; miRNA binding; mRNA 3'-UTR binding; N6-methyladenosine-containing RNA binding; pre-mRNA intronic binding; protein binding; RNA binding; single-stranded telomeric DNA binding
Biological Process:  G-quadruplex DNA unwinding; interleukin-12-mediated signaling pathway; miRNA transport; mRNA export from nucleus; mRNA processing; mRNA splicing, via spliceosome; negative regulation of mRNA splicing, via spliceosome; negative regulation of transcription by RNA polymerase II; positive regulation of telomerase RNA reverse transcriptase activity; positive regulation of telomere maintenance via telomere lengthening; primary miRNA processing; RNA metabolic process; RNA transport
Disease: Inclusion Body Myopathy With Early-onset Paget Disease With Or Without Frontotemporal Dementia 2
Reference #:  P22626 (UniProtKB)
Alt. Names/Synonyms: DKFZp779B0244; epididymis secretory sperm binding protein; FLJ22720; heterogeneous nuclear ribonucleoprotein A2/B1; heterogeneous nuclear ribonucleoprotein B1; Heterogeneous nuclear ribonucleoproteins A2/B1; hnRNP A2 / hnRNP B1; hnRNP A2/B1; HNRNPA2; HNRNPA2B1; HNRNPA2B1/MYC fusion; HNRNPB1; HNRPA2; HNRPA2B1; HNRPB1; IBMPFD2; nuclear ribonucleoprotein particle A2 protein; RNPA2; ROA2; SNRPB1
Gene Symbols: HNRNPA2B1
Molecular weight: 37,430 Da
Basal Isoelectric point: 8.97  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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hnRNP A2/B1

Protein Structure Not Found.


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