OSBP Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability. Belongs to the OSBP family. Widely expressed. Note: This description may include information from UniProtKB.
Protein type: Lipid-binding
Chromosomal Location of human Ortholog: 11q12.1
Cellular Component:  cell junction; cytoplasm; cytosol; endoplasmic reticulum membrane; Golgi apparatus; Golgi membrane; membrane; nucleolus; nucleoplasm; nucleus; perinuclear region of cytoplasm; trans-Golgi network
Molecular Function:  oxysterol binding; phosphatidylinositol-4-phosphate binding; protein binding; protein domain specific binding; sterol transporter activity
Biological Process:  bile acid biosynthetic process; intracellular cholesterol transport; positive regulation of growth of symbiont in host; sterol transport
Reference #:  P22059 (UniProtKB)
Alt. Names/Synonyms: OSBP; OSBP1; oxysterol binding protein; Oxysterol-binding protein 1
Gene Symbols: OSBP
Molecular weight: 89,421 Da
Basal Isoelectric point: 6.91  Predict pI for various phosphorylation states
Select Structure to View Below

OSBP

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene